Tacrolimus Rescue Therapy for Cyclosporine-Induced Nephrotoxicity
Transplant international(1998)
Abstract
Following renal transplantation, the long-term use of cyclosporine can cause nephrotoxicity. This small study of ten patients looks at the effects of tacrolismus rescue therapy over a 6-month period. After conversion to tacrolismus, renal function improved in seven pateints, progressive graft dysfunction slowed and almost stabilized in two patients, and, in the remaining patient, deterioration continued and hemodialysis treatment was initiated at the end of the study period. A greater number of patients and a longer follow up are necessary to confirm these initially impressive results.
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Key words
Key words Cyclosporine-induced nephrotoxicity,Tacrolismus rescue therapy,Arteriolopathy,Renal transplantation
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