Piperidinylpyrroles: Design, Synthesis And Binding Properties Of Novel And Selective Dopamine D4 Receptor Ligands
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1999)
摘要
Piperidinylpyrroles of type 3 were synthesized through a modified Paal-Knorr reaction. For the introduction of pyrrole-substituents high yielding transformations including Sonogashira cross-coupling reactions were utilized. Employment of the reagent TosMIC gave access to the regioisomeric oxazolyl derivatives 7 and 11 which showed the highest dopamine D4 receptor binding of the series investigated. (C) 1999 Elsevier Science Ltd. All rights reserved.
更多查看译文
关键词
dopamine,receptor binding
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要