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Synthesis And Biological Activity Of Peptidyl Aldehyde Urokinase Inhibitors

Susan Y Tamura,Michael I Weinhouse,Christopher A Roberts,Erick A Goldman,Kevin Masukawa,Susanne M Anderson,Cheryl R Cohen,Annette E Bradbury,Vernon T Bernardino,Steven A Dixon,Michael G Ma,Thomas G Nolan,Terence K Brunck

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2000）

Cited 47|Views23
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Abstract
Solid- and solution-phase synthesis of peptidomimetic inhibitors of urokinase-type plasminogen activator based on the sequence dSerAlaArg-al are described. The biological activities of these unique inhibitors are reported herein. Carbonate prodrugs were prepared and tested as potential drug delivery systems. (C) 2000 Published by Elsevier Science Ltd.
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