Inhibitory effects of guarana seed extract on passive cutaneous anaphylaxis and mast cell degranulation.

Tomoko Jippo,Yuko Kobayashi,Harumi Sato,Atsushi Hattori,Hiroaki Takeuchi,Keiichiro Sugimoto,Munekazu Shigekawa

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY（2009）

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摘要

This study investigated the effects of guarana seed extract (GSE) on an anti-allergic mechanism. GSE orally administered inhibited the anti-dinitrophenol IgE-induced passive cutaneous anaphylaxis reaction in mice. Furthermore, it inhibited the degranulation of rat basophilic leukemia RBL-2H3 cells. It had no cytotoxicity on RBL-2H3 cells. These results show that GSE is a candidate for effective therapeutic material for allergic diseases.

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关键词

mast cell,degranulation,passive cutaneous anaphylaxis,anti-allergic effect,guarana

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