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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate

Jill Wood,Cedo M. Bagi,Christiana Akuche, Antonietta Bacchiocchi,Jeremy Baryza,Marie-Luise Blue,Catherine Brennan,Ann-Marie Campbell,Soongyu Choi,James H. Cook,Patricia Conrad,Brian R. Dixon,Paul P. Ehrlich,Todd Gane,David Gunn,Ted Joe,Jeffrey S. Johnson,Jerold Jordan,Richard Kramss,Peiying Liu

Bioorganic & Medicinal Chemistry Letters（2006）

Cited 30|Views35
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Abstract
A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17β-HSD II for the treatment of osteoporosis. Biochemical data for several compounds are given. Compound 42 was selected as the lead candidate.
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Key words
Pyrrolidinone,Hydroxysteroid dehydrogenase,Inhibitor,Osteoporosis
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