Ancistrolikokines A−C: New 5,8‘-Coupled Naphthylisoquinoline Alkaloids fromAncistrocladuslikoko1
JOURNAL OF NATURAL PRODUCTS(2000)
Abstract
Three new naphthylisoquinoline alkaloids, ancistrolikokines A-C (1-3), have been isolated and structurally assigned from Ancistrocladus likoko, as well as the known compound korupensamine A (4). Their 5,8'-coupling hints at a close biogenetic relationship of A. likoko to other Central African Ancistrocladus species. Compounds 1-4 showed good to moderate antimalarial activities when evaluated in vitro against the NF54 and K1 strains of Plasmodium falciparum.
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