Relationship between HPV infection and expression of HIF-1α and VEGF in head and neck squamous cell carcinoma and its prognostic value

Journal of Shanghai Jiaotong University(Medical Science)(2013)

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Abstract
Objective: To investigate the relationship between human papillomavirus (HPV) infection and expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in tissues of head and neck squamous cell carcinoma (HNSCC), and explore its clinical significance. Methods: The infection of HPV6/11, 16/18, 31/33 was examined by in situ hybridization in 43 samples of HNSCC, and the expression of HIF-1α and VEGF was determined by immunohistochemistry method. Spearman method was employed for rank correlation analysis, overall survival of patients was calculated by Kaplan-Meier method, and Cox regression model was used for multivariate analysis. Results: In the 43 cases of HNSCC, the positive infection rate of HPV was 25.6%, and the positive expression rates of HIF-1α and VEGF were 65.1% and 51.2% respectively. The expression of HIF-1α was related to T stage, N stage and clinical stage (P < 0.05), and the expression of VEGF was related to N stage and recurrence (P < 0.05). The expression of HIF-1α was positively related with the expression of VEGF (r=0.359, P < 0.05). There was no significant difference in the expression of HIF-1α and VEGF between HPV positive group and HPV negative group (P > 0.05). The 3-year overall survival rates of HPV positive group and HPV negative group were 60.0% and 59.7% respectively (P > 0.05), those of HIF-1α positive expression group and HIF-1α negative expression group were 49.9% and 80.0% respectively (P=0.06), and those of VEGF positive expression group and VEGF negative expression group were 41. 2% and 81. 0% respectively (P < 0.05). Conclusion: HIF-1α and VEGF may be considered as parameters in evaluation of progression, metastasis and prognosis of HNSCC, and the correlation between HPV infection and expression of HIF-1α and VEGF in tissues of HNSCC is undetermined.
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Key words
Head and neck squamous cell carcinoma,Human papillomavirus,Hypoxia inducible factor,Prognosis,Vascular endothelial growth factor
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