Expressions of PS2 and platelet activating factor affected by Jianwei Yuyang Granule on helicobacterpylori-associated gastritis and their effect on epithelial apoptosis

Objective: To observe the expressions of PS2 and platelet activating factor (PAF) affected by Jianwei Yuyang (JWYY) Granule on helicobacterpylori-associated gastritis and study the possible mechanism. Methods: A total of 80 cases of helicobacterpylori-associated gastritis were randomly divided into two groups. The JWYY group consisted of 42 cases who were treated with JWYY granule and the control group had 38 cases who were given three combined western medicines. Urease test and Warthin-Starry method were used to detect H. pylor on biopsy specimens of gastric mucus, and Western blot method was used to observe the expressions of PS2 and platelet activating factor (PAF) affected by Jianwei Yuyang. TUNEL technique mediated by termina enzyme was used to detect the apoptotic body. All the cases who had taken JWYY granule were rechecked with gastroscope at the 6th week. Results: The difference in apoptotic index between JWYY group and control group differed significantly, with the total efficacy of JWYY higher than that in control group (P < 0.05). The Western blot method showed that JWYY Granule could reduce the gastic mucosa's expression of PAF, elevate the expression of PS2, but in the control group PS2 and PAF were little affected. Conclusion: JWYY can kill H. pylori, reduce the gastic mucosa's expression of PAF, elevate the expression of PS2 to suppress apoptosis. This may be the possible mechanism of JWYY for curing PU.