Non-Peptidic Hiv Protease Inhibitors: C-2-Symmetry-Based Design Of Bis-Sulfonamide Dihydropyrones

Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide inhibitor/HIV protease complexes suggested incorporation of a second, C-2 symmetry-related sulfonamide group. Selected bis-sulfonamide dihydropyrone analogues display high HIV protease inhibitory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.