Gh(3) Cells, An Anterior-Pituitary Cell-Line, Express Cck-B Receptors
PEPTIDES(1993)
Abstract
We found that GH-3 cells, a rat anterior pituitary tumor cell line, expressed a single class of high-affinity binding sites for radiolabeled cholecystokinin octapeptide (CCK-8) with a K(d) of 48 pM. The binding sites had high affinity for CCK-8, CCK-4, gastrin I, and L-365,260 (CCK-B antagonist), and had low affinity for devazepide (CCK-A antagonist), indicating that the binding sites are CCK-B receptors. GTP and its stable analogues inhibited radiolabeled CCK-8 binding to GH-3 cell membranes, suggesting a coupling of CCK-B receptors to a G-protein.
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Key words
CHOLECYSTOKININ, CCK-B RECEPTOR, ANTERIOR PITUITARY CELL LINE, GH3 CELLS, L-365,260, DEVAZEPIDE
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