ChemInform Abstract: Reactions of Alkyl Radicals with Oxime Ether: One-Pot Synthesis of α-Amino Acids.
Cheminform(2010)
Abstract
The addition of water-resistant carbon radicals to glyoxylic oxime ether provided a new method for the one-pot synthesis of alpha-amino acids via a carbon-carbon bond formation. The reaction of 2-hydroxy-2-methoxyacetic acid methyl ester with benzyloxyamine and an alkyl radical gave the protected alpha-amino acids via the stannyl radical-mediated reaction. In the absence of Bu3SnH, the predominant formation of the desired alkylated products was also observed by using RT and Et3B in boiling toluene. Et2Zn could serve as an initiator of these radical reactions as well as Et3B. (C) 2000 Elsevier Science Ltd. All rights reserved.
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Key words
amino acid,amino acids
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