Hochauflösende T1-gewichtete MR-Lymphographie inguinaler Lymphknoten nach interstitieller Applikation von Gadomer-17 im Tierexperiment

Purpose: To evaluate the microstructural anatomy of inguinal lymph nodes in pigs after interstitial MR-lymphography with the dendritic contrast agent Gadomer-17. Material and Methods: High-resolution T1-weighted MR-lymphography was performed in inguinal lymph nodes of 10 domestic pigs (39-46 kg) after subcutaneous injection of 10 mu mol/kg body weight Gadomer- 17 in the hind legs of the animals. A 1.5T MR scanner and a ring-shaped surface coil were used. Two different high-resolution gradient-echo sequences with additionally reconstructed maximum-intensity projections were evaluated in a total of 20 lymph nodes. The high-resolution MR-findings were correlated with the histologic sections of the excised inguinal lymph nodes. Results: Coronal T1-weighted 3D gradient-echo images TR = 20 msec, TE = 6.1-8.3 msec, FA = 20 degrees) with a slice thickness of I mm, a field-of-view of 120 mm and a matrix size of 256 x 256 (reconstructed to 1024 x 1024 voxels) yielding a reconstructed in-plane resolution of 117 x 117 mu m(2) were best suited for the high-resolution MR lymphography of inguinal lymph nodes and enabled the differentiation of the hyperintense lymph node sinuses and hypointense lymphoid parenchyma of each lymph node (100%). Even dilated lymphatic vessels evident in the histologic specimen were best demonstrated on the MIP images. Conclusion: High-resolution interstitial MR lymphography with Gadomer-17 allows the visualization of different tissue compartments of inguinal lymph nodes. This new technique is feasible on a routine 1.5T scanner and may offer potential for the detection of micro-metastases in lymph nodes of cancer patients.