Ionophores - Potential Screening Via Supercritical-Fluid Chromatography Combined With Mass-Spectrometry And Tandem Mass-Spectrometry

A variety of ionophores have been studied by packed column supercritical-fluid chromatography combined with mass spectrometry. One of the ionophores, lasalocid, provided particularly good multiple-reaction monitoring signal-to-noise responses when analysed by tandem mass spectrometry and this approach shows considerable potential for the analysis of this compound in medicated animal feeds. A capillary supercritical-fluid chromatograph has been interfaced to an unmodified benchtop quadrupole mass spectrometer and this combination has enabled the molecular weight determination of the sodium salt of an ionophore.