A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.
Bioorganic & Medicinal Chemistry(2009)
摘要
The discovery of trans-4-substituted cyclohexanecarboxylic acid derivative 11b as a novel and potent VLA-4 antagonist is reported.
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关键词
VLA-4,Integrin,trans-4-Substituted cyclohexanecarboxylic acid,Pharmacophore
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