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The Discovery Of High Affinity Agonists Of Gpr109a With Reduced Serum Shift And Improved Adme Properties

Jason E. Imbriglio,Daniel Dirocco, Rena Bodner,Subharekha Raghavan,Weichun Chen,Daria Marley,Craig Esser,Tom G. Holt,Michael S. Wolff,Andrew K. P. Taggart,M. Gerard Waters,James R. Tata,Steven L. Colletti

Bioorganic & medicinal chemistry letters（2011）

Cited 13|Views55
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Abstract
Amino-anthranilic acid derivatives have been identified as a new class of low serum shifted, high affinity full agonists of the human orphan G-protein-coupled receptor GPR109a with improved ADME properties. (C) 2010 Elsevier Ltd. All rights reserved.
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Key words
Niacin,Atherosclerosis,Anthranilic acid
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