湖南地区汉族人群hsa-miR-196a2基因多态性与鼻咽癌发病风险及临床病理因素的关系

Journal of Guangdong Medical College(2013)

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Abstract
目的研究hsa-miR-196a2基因多态性位点rs11614913与鼻咽癌发病风险及临床病理因素的关系。方法采用病例对照分析方法,对湖南地区162例汉族人鼻咽癌患者(病例组)及性别、年龄相匹配的135例正常人(对照组)的hsa-miR-196a2基因多态性位点rs11614913的基因型进行PCR-RFLP检测,观察该位点多态性分布与鼻咽癌发病风险及临床病理特点的关系。结果病例组和对照组hsa-miR-196a2基因多态性位点rs11614913基因型频率分布差异无统计学意义(P>0.05),且该位点基因型分布与鼻咽癌患者的临床病理因素无关(P>0.05)。结论 hsa-miR-196a2基因多态性位点rs11614913与湖南地区汉族人鼻咽癌发病风险及临床病理因素无关。
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Key words
polymorphism,nasopharyngeal carcinoma,rs11614913,hsa-miR-196a2
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