Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists.
Bioorganic & Medicinal Chemistry Letters(2005)
Abstract
The synthesis and SAR of constrained dihydroimidazoimidazoles, and behavioral activity of compounds 7b (Ki 42nM) and 7k (Ki 41nM) in a mouse canopy model of anxiety, are reported.
MoreTranslated text
Key words
Corticotropin-releasing factor 1 receptor antagonists,SAR,Anxiolytic activity,Mouse canopy model
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined