Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists.
Bioorganic & Medicinal Chemistry Letters（2005）
Abstract
The synthesis and SAR of constrained dihydroimidazoimidazoles, and behavioral activity of compounds 7b (Ki 42nM) and 7k (Ki 41nM) in a mouse canopy model of anxiety, are reported.
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Key words
Corticotropin-releasing factor 1 receptor antagonists,SAR,Anxiolytic activity,Mouse canopy model
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