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静脉注射地尔硫(艹卓)对人心脏电生理的影响

Shaanxi Medical Journal(2006)

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Abstract
目的:探讨静脉应用地尔硫(艹卓)对心脏电生理的影响.方法:38例阵发性室上性心动过速患者消融成功后的自愿者,静脉给予地尔硫(艹卓),首剂0.2mg/kg静脉推注(稀释至10~15ml,5min内推完),继续以1~5μg(kg·min)维持滴注,30min后开始测量相关数值.结果:心率减慢,房室结传导时间及有效不应期延长,心房及心室的有效不应期缩短均有统计学差异,心房内的传导时间(高右房起搏至希氏束A波的时间)及HV的传导时间不受影响,心房内的离散度无明显统计学差异.无一例在试验过程中出现窦性心动过缓、窦性停搏及房室传导阻滞发生.结论 :静脉滴注地尔硫(艹卓)对心率、房室结的影响是有限的,对窦房结和房室结功能正常者应用是安全的.
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Key words
Supraventricular/physiopathology Diltiazem/pharmacology Electrophysiologic Techniques,Tachycardia,Cardiac Infusions,Intravenous
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