Functional analysis of CD8+ T cell responses to the onconeural self protein cdr2 in patients with paraneoplastic cerebellar degeneration
Journal of Neuroimmunology(2008)
摘要
Paraneoplastic cerebellar degeneration (PCD) is linked to an immune response against cerebellar degeneration related antigen 2 (cdr2) co-expressed in tumor and Purkinje neurons. Here, comprehensive immune-assessment assays were used to analyze CD8+ T cells from 7 PCD patients, but no evidence was found of CD8+ T cells specific for either of two previously described cdr2 epitopes (cdr2-1 and cdr2-2). In contrast, viral-specific CD8+ T cells from healthy volunteers and PCD patients were measurable. These findings are inconsistent with an obligate role for cdr2-1- or cdr2-2-specific CD8+ T cells in the pathogenesis of PCD.
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关键词
Paraneoplastic cerebellar degeneration,Cancer,Cerebellar degeneration related antigen 2,T lymphocyte
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