Discovery of Orally Active, Pyrrolidinone-Based Progesterone Receptor Partial Agonists

David G. Washburn,Tram H. Hoang,James S. Frazee,Latisha Johnson,Marlys Hammond,Sharada Manns,Kevin P. Madauss,Shawn P. Williams,Chaya Duraiswami,Thuy B. Tran,Eugene L. Stewart,Eugene T. Grygielko,Lindsay E. Glace,Walter Trizna,Rakesh Nagilla,Jeffrey D. Bray,Scott K. Thompson

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2009）

引用 11|浏览48

关键词

Progesterone receptor,Agonist,Partial agonist,Endometriosis,Nuclear receptors,Hormone receptors,hERG binding,Androgen receptor,OVX rat model,Progestin

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