Interactions Of The Dimethyldiazaperopyrenium Dication With Nucleic-Acids .1. Binding To Nucleic-Acid Components And To Single-Stranded Polynucleotides And Photocleavage Of Single-Stranded Oligonucleotides

The binding of dimethyldiazaperopyrenium dication (1) with nucleosides, nucleotides, and single-stranded polynucleotides has been studied by photophysical methods. It has been shown that 1 may be a potential selective fluorescent probe for A- and/or T-rich polynucleotides. 1 efficiently cleaves oligonucleotides at guanine sites, under illumination with visible light, and therefore may be used as a sequence-specific artificial photonuclease.