Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and -5.

Akihito Dan,Takaaki Shiyama,Kazuto Yamazaki,Naoto Kusunose,Katsuya Fujita,Hideshi Sato,Kazutaka Matsui,Masafumi Kitano

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

HTS and the following synthesis of a series of compounds led us to the discovery of hydroxamic acid analogs as potent dual inhibitors of phosphodiesterase (PDE)-1 and -5. Some of them showed the expected potent vasodilatory effects with a rising level of cGMP.

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Phosphodiesterase

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