The Role Of Aberrant Promoter Methylation (Pm) Of Tumor Suppressor Genes (Tsg) P161nk4a And P14arf In Carcinogenesis Of Ulcerative Colitis (Uc)

specifically in the distal colon.Histopathologacal and molecular (Cdx2 genomic and expression pattern, Ki67 labeling, beta-catenin distribution) analyses indicate that these tumors are invasive adenocarcinomas that recapitulate the malignant sequence observed in the majority of sporadic colorectal cancers in human.Conclusion.The results demonstrate that Cdx2 is a new tumor suppressor gene which is specific of colorectal cancer.This action at the adult stage is functionally and geographically distinct from the homeotic role during gut development.