复方桂枝茯苓丸对脑缺血再灌注损伤大鼠NOS、Na~+-K~+-ATPase的影响

Journal of Sichuan of Traditional Chinese Medicine（2009）

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Abstract

目的:观察复方桂枝茯苓丸对脑缺血再灌注损伤(CRI)大鼠一氧化氮合酶(NOS)、Na+-K+-ATP酶(Na+-K+-ATPase)的影响。方法:用结扎双侧颈总动脉45min后再通法,制备CRI大鼠模型,用复方桂枝茯苓丸、血塞通治疗,给药2周,检测血清与脑匀浆NOS活性、脑匀浆Na+-K+-ATPase活性变化。结果:复方桂枝茯苓丸能降低CRI大鼠血清与脑匀浆NOS活性,升高大鼠脑匀浆Na+-K+-ATPase活性。结论:复方桂枝茯苓丸对CRI大鼠具有治疗作用。

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Key words

Na+K+-ATPase,NOS,CRI,Compound Guizhifuling pill

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