Amide derivatives with H1-antihistaminic effect.

C Saturnino,P Saturnino,G De Martino,J C Lancelot,D Perrine,R Boureau,M Robba

Pharmaceutica Acta Helvetiae（1998）

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摘要

The synthesis and the structure-activity correlation of a series of N-aminoalkylacetamides as H1-antihistaminic agents have been carried out. The compounds were tested in vitro by measurement of the inhibition of histamine-induced contractions on isolated guinea pig ileum; the results are expressed as pA2.

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关键词

N-aminoalkylacetamides,H1-antihistaminic agents,Structure-activity correlation

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