Hippocampal Metabolic Alterations in Amyotrophic Lateral Sclerosis: A Magnetic Resonance Spectroscopy Study.
Life (Basel, Switzerland)(2023)
Abstract
Hippocampal 1H-MRS may not only contribute to a better academic understanding of extra-motor disease burden in ALS, but given its sensitive correlations with validated clinical metrics, it may serve as practical biomarker for future clinical and clinical trial applications. Neuroimaging protocols in ALS should incorporate MRS in addition to standard structural, functional, and diffusion sequences.
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Key words
amyotrophic lateral sclerosis,grey matter,hippocampus,magnetic resonance spectroscopy,memory,metabolites,perforant pathway,tractography,white matter
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