Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration.
Bioorganic & Medicinal Chemistry（2007）
Abstract
A series of 5β-methylprolyl-2-cyanopyrrolidine analogs were synthesized and identified as long-acting DPP-IV inhibitors. The mode of binding and the effect on the plasma glucose level were evaluated.
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Key words
DPP-IV inhibitor,Prolyl-2-cyanopyrrolidine
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