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Preparation of [14C]G2.5 and [14C]G5.5 Starburst® PAMAM dendrimers: the first example of dendrimer radiosynthesis

Brad D. Maxwell,Hideji Fujiwara,Sohrab Habibi-Goudarzi,Justin P. Ortiz,Sherry J. Logusch

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS（1998）

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Abstract
A procedure for preparing C-14-labelled half-generation Starburst(R) PAMAM dendrimers is described. Controlled incorporation of radioisotope was achieved by Michael additions of amines with C-14-labelled methyl acrylate, resulting in dendrimers with specific activities between 30 and 45 mCi/mmor in very high radiochemical purity.
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C-14-labelled half-generation Starburst (R) PAMAM dendrimers,synthesis
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