Structure–activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues
Bioorganic & Medicinal Chemistry(2009)
Abstract
In a series of carbolines, azaindoles and pyrrolo(iso)quinolines, 2-methyl-β-carboline (9) showed the highest in vitro activity (IC50=0.45μM) against Plasmodium falciparum K1, without apparent cytotoxicity against L6 cells (SI>1000).
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Key words
Indoloquinoline alkaloid,Indoloisoquinoline,Carboline,Azaindole,Pyrroloquinoline,Pyrroloisoquinoline,Antiparasitic,Antiplasmodial,Antimalarial,Cytotoxic
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