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Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer

Koichiro Harada,Hideki Kubo,Yoshitaka Tomigahara,Kazuhiko Nishioka,Junya Takahashi,Mio Momose,Shinichi Inoue,Atsuyuki Kojima

Bioorganic & Medicinal Chemistry Letters（2010）

Cited 46|Views7
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Abstract
Compound 4p was identified as a potent selective inhibitor of 17β-HSD3 resulting in the discovery of a novel lead series for further optimization.
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