Allogeneic CD3/CD28 cross-linked Th1 memory cells provide potent adjuvant effects for active immunotherapy of leukemia/lymphoma
Leukemia Research(2009)
摘要
The breaking of peripheral T-cell tolerance toward self-antigens expressed by tumor cells and the subsequent establishment of an effective tumor protective immune response remains a major challenge for cancer immunotherapy. We report that both protective and therapeutic anti-tumor immune responses can be achieved in a mouse leukemia/lymphoma tumor model through the strong adjuvant effects provided by allogeneic CD3/CD28 cross-linked Th1 memory cells. The adjuvant effect of these cells is mediated by their ability to produce a variety of ‘danger signals’ which serve to deviate native non-protective Th2 anti-leukemia immune responses to effective Th1 immune responses.
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关键词
Active immunotherapy,Cancer vaccine,Adjuvant,Cryoimmunotherapy,Immunomodulation,Th1/Th2 immunity,B-cell leukemia/lymphoma
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