多西紫杉醇联合替吉奥治疗蒽环类耐药晚期三阴乳腺癌疗效观察

Journal of Basic and Clinical Oncology(2013)

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Abstract
目的观察多西紫杉醇联合替吉奥治疗蒽环类耐药晚期三阴乳腺癌(TNBC)的临床疗效和毒副反应。方法采用多西紫杉醇联合替吉奥治疗46例蒽环类耐药的晚期TNBC患者,3周为1周期,治疗2周期后评价疗效及毒副反应。结果 46例患者中,CR 1例,PR 15例,SD 18例,PD 12例,有效率34.8%,疾病控制率73.9%。主要毒副反应为骨髓抑制和胃肠道反应,无化疗相关死亡患者。结论多西紫杉醇联合替吉奥治疗蒽环类耐药晚期TNBC有效,毒副反应轻,患者耐受性好。
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advanced triple-negative breast cancer,docetaxel,anthracycline,S-1
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