Internal ribosome entry site of Rhopalosiphum padi virus is functional in mammalian cells and has cryptic promoter activity in baculovirus-infected Sf21 cells.
Acta pharmacologica Sinica（2008）
Abstract
RhPV IRES can mediate gene expression in both insect cells and mammalian cells, and this characteristic of the RhPV IRES will facilitate the development of a bicistronic baculovirus gene therapy vectors.
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Key words
baculovirus,cryptic promoter,gene therapy,internal ribosome entry site,Rhopalosiphum padi virus
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