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尖锐湿疣患者荧光定量PCR检测结果分析

Chinese Journal of AIDS & STD(2006)

Cited 13|Views4
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Abstract
目的探讨尖锐湿疣患者疣体中人乳头瘤病毒(HPV)分型、基因含量及其意义。方法采用荧光定量PCR技术(FQ-PCR)检测尖锐湿疣患者疣体中HPV-DNA含量及其型别。结果169例尖锐湿疣患者经FQ-PCR检测后168例(99.41%)阳性,其中HPV6/11型阳性150例(88.76%),平均1.2×107拷贝/ml;HPV16/18型阳性13例(7.69%),平均2.3×106拷贝/ml;HPV6/11和HPV16/18型同时阳性5例(2.96%),平均1.0×107拷贝/ml;4型均阴性1例(0.59%),定量为0×10拷贝/ml。结论HPV6/11型是尖锐湿疣发病的主要型别,尖锐湿疣患者疣体中HPV-DNA含量与其是否复发无明显关系,FQ-PCR可作为尖锐湿疣早期诊断的指标。
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Key words
Recurrence.,Condylomata acuminata,Papillomavirus,Fluorescence quantitative polymerase chain reaction
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