冠心病合并糖尿病患者晚期糖基化终产物测定分析
Clinical Focus(2010)
Abstract
目的探讨血清晚期糖基化终产物(AGEs)水平在冠心病(CAD)合并糖尿病(DM)患者中的意义。方法诊断明确的CAD合并DM患者82例,根据冠状动脉造影结果分为单支病变组、双支病变组及3支病变组,分别测定血清AGEs、空腹血糖(FPG)、血脂,计算体质量指数(BMI),对3组间AGEs、FPG、血脂、BMI进行比较。结果AGEs水平随冠状动脉病变支数增加而增高,单支病变组(35.86±11.28)ng/L,双支病变组(43.52±17.29)ng/L,3支病变组(62.09±14.23)ng/L,差异有统计学意义(P<0.05);Spearman相关分析显示,AGEs与总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、FPG均呈正相关(P<0.05);多元逐步线性回归分析显示,LDL-C、FPG与AGEs独立相关。结论AGEs促进DM患者冠状动脉粥样硬化的发展,控制FPG及LDL-C可能延缓此作用。
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Key words
coronary disease,LDL,blood glucose,advanced,glycosylation end products,cholestrol
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