Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases.
Bioorganic & Medicinal Chemistry Letters(2010)
摘要
Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K(i)) as well as excellent activity in human whole blood. These studies led to the discovery of highly potent TACE inhibitors with good DMPK profiles.
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关键词
inhibitors,enzyme,tace
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