Clinical Study of Infant Hand-foot and Mouth Disease Caused by Enterovirus 71 and Other Enterovirus in HeZe

Objective:To investigate the clinic difference between infant hand-foot and mouth disease caused by enterovirus 71 and other enterovirus. Methods:The 320cases who were suffered from hand-foot and mouth disease of designated hospitals in HeZe were retrospectively analyzed and stool specimens of all children were collected. The cases caused other enterovirus were chosn as control group. Results:106 cases are caused by EV71, the rest were caused by other enterovirus. ⑴The incidence for boys and girls are the same, mainly in 1 to 3-year-old children and patients in rural areas were more than that in urban. ⑵The symptoms of cases caused by EV71 are high fever, neurological symptoms, and no rash; The peripheral blood and blood sugar in majority cases are increased; The myocardial of majority are injured; There were ECG abnormalities, and chest X-ray, EEG and magnetic resonance imaging abnormalities in.some cases. ⑶ The symptoms of cases caused by other enterovirus are Skin rash, fever, upper respiratory symptoms and minority of cases with mental difference. Nervous system symptoms are not appeared. Peripheral blood and blood sugar of cases are increased in some cases. There were some complicated with myocardial damage, but there were not abnormal in chest and X-ray. ⑷There were 50 cases caused by EV71 infection in 56 children who had abnormal nervous system Conclusions:The hand-foot-mouth disease caused by EV71 is a dangerous disease that can easily lead to central nervous damage and pulmonary. Early identification and timely treatment in severe cases is very important. To universe detection of pathogens is helpful in improving diagnosis and treatment capacity and enhance understanding of the disease can reduce morbidity and mortality.