Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.

C/Si switch: Twofold sila-substitution (C/Si exchange) in the RARα-selective retinoids 1 a (AM80) and 2 a (AM580) leads to 1 b (disila-AM80) and 2 b (disila-AM580), respectively. The chemistry and biology of the C/Si pairs are reported. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.