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The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity.

Fumitada Tsuji,Ko Kobayashi,Masahiro Okada,Hisao Yamaguchi,Makoto Ojika,Youji Sakagami

Bioorganic & Medicinal Chemistry Letters（2011）

Cited 21|Views14
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Abstract
Research of structure–activity relationships on ComXRO-E-2 pheromone, a quorum sensing pheromone, indicates Phe-Trp∗(Ger)-NH2 is a minimal pharmacore.
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Key words
Bacillus subtilis,ComX pheromone,Posttranslational modification,Quorum sensing,Structure–activity relationships
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