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Synthesis and Characterization of Artificial Ribonucleases

N. S. Zhdan,I. L. Kuznetsova,M. A. Zenkova,A. V. Vlassov,V. N. Silnikov,R. Giege,V. V. Vlassov

NUCLEOSIDES & NUCLEOTIDES（1999）

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Abstract
RNA cleaving molecules were synthesized by conjugating components of ribonucleases A and T1 catalytic centers (imidazole, aliphatic amino and/or carboxy residues) to intercalating and cationic structures. The artificial ribonucleases were shown cleave RNA at Py-Pu sites in single-stranded regions.
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synthesis
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