Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-HETE synthase inhibitors.

Toshio Nakamura,Takaaki Ishii,Noriyuki Miyata,Kazuo Taniguchi,Yasumitsu Tomishima,Tomokazu Ueki,Masakazu Sato

Bioorganic & Medicinal Chemistry Letters（2005）

引用 9|浏览7

暂无评分

摘要

Structural modification of the novel 20-HETE synthase inhibitor 1 (IC50 310nM) is described. Introduction of a side chain with a carboxylic acid at the terminal position to 1 resulted in increased ability to inhibit human renal microsomal production of 20-HETE (7c: IC50 7.9nM), with good selectivity toward CYP2D6 and cyclooxygenases (COX)-1 and -2.

查看译文

关键词

20-HETE

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要