JNK3通过与RelA/p65相互作用抑制NF-κB信号通路减弱Bel-7402细胞的黏附能力(英文)

L I Qiang,HAN Qing,YU Dong-Hui,TANG Liu-Jun,WANG Jian,WANG Xiao-Hui,XU Wang-Xiang,ZHAN Yi-Qun,LI Chang-Yan,GE Chang-Hui, Y U Miao,YANG Xiao-Ming

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS（2012）

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Abstract

JNK信号通路在细胞的炎症、增殖与凋亡等生物学过程中发挥了重要的作用.我们采用酵母双杂交技术发现转录因子p65是JNK3的相互作用蛋白质.体内体外实验均证实JNK3与p65存在蛋白质相互作用.报告基因实验结果表明过表达JNK3抑制TNFα诱导NF-κB介导的转录激活.EMSA结果证明JNK3减弱NF-κB的DNA结合能力.实时定量PCR结果表明JNF3减少NF-κB靶基因的表达.综上所述,我们的研究结果表明JNK3做为一个调节分子在体内发挥了抑制p65转录活性的功能.

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Key words

JNK3,NF-kappa B,p65,cell adhesion,protein-protein interaction

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