[486] UNDERSTANDING HBV RESISTANCE TO TELBIVUDINE: MOLECULAR MODELLING AND DATABASE MINING

Results: Compared to controls, HCC patients had a higher prevalence of genotype C [57.4% vs 7 I .7%respectively, p = 0.00 I , O.R. I .9(95% CT I .3-2.8)] and CP mutations [66.8% vs. 88.1% respectively, p i 0.001, O.R. 3.7 (95% CT 2.1-6.3)].Prevalence of precore mutations was comparable between 2 groups.Multivariate analysis revealed CP mutations as the only independent risk factor for HCC (p i 0.001).CP mutations was associated with a specific sequence V1753 (p = 0.002), which is associated with HCC (Tanaka, J Hepatol2006).The ROC curve of HBV DNA levels for HCC is shown.With the AUC of 0.508, there was no lower limit of HBV DNA level associated with lower chance of HCC.Conclusions: CP mutation was an independent risk factor for HCC.Its relationship with T I753 with respect to hepatocarcinogenesis needs further investigations.There was no HBVDNA level associated with lower risk for HCC.