Quantitative study of osteoclastic related factors in the process of bone reconstruction]
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology(2006)
摘要
To detect the expression of osteoclast related factors, tumor necrosis factor-alpha (TNF-alpha), receptor activator of NF-kappaB ligand (RANKL) and tartrate-resistant acid phosphatase (TRAP), in the process of bone remodeling.8-week-old male C57BL/6J mice were employed in this study to detect the expression of osteoclast related factors by real time PCR.TNF-alpha, RANKL and TRAP were up regulated in the process of bone remodeling, they reached the peak on day 2, 5 and 10 individually after injury.Osteoclast related factors also participate in bone remodeling, which depends on the delicate balance between bone formation and bone resorption.
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关键词
bone remodeling,tumor necrosis factor,tartrate-resistant acid phosphatase,real time polymerase chain reaction,receptor activator of nf-κb ligand
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