Preparation of Monofluorophenols via the Reaction of Difluorobenzene Derivatives with Potassium Trimethylsilanoate

Jianqing Li,Daniel Smith,Jennifer Qiao,Stella Huang,Subramaniam Krishnananthan,Henry Wong,Mark Salvati,Balu Balasubramanian,Bang-Chi Chen

SYNLETT（2009）

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摘要

An efficient synthesis of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate in moderate to excellent yields is described. High regioselectivity was observed in some cases.

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关键词

fluorophenols,synthesis,regioselective,aromatic,substitution

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