Folate Receptor Positive Macrophages: Cellular Targets For Imaging And Therapy Of Inflammatory And Autoimmune Diseases
TARGETED DRUG STRATEGIES FOR CANCER AND INFLAMMATION(2011)
Abstract
FR beta constitutes a unique and selective marker for activated human monocytes and macrophages. Based on numerous criteria, most FR+ macrophages appear to be highly inflammatory and important in the development/maintenance of many inflammatory and autoimmune diseases, however, some appear to be activated and anti-inflammatory. Inflammatory pathologies in which FR+ macrophages are commonly enriched include rheumatoid arthritis, Crohn's disease, atherosclerosis, sarcoidosis, glomerulonephritis, osteoarthritis, organ transplant rejection, ulcerative colitis, Sjogren's syndrome, diabetes, ischemia/reperfusion injury, impact trauma, microbial infection, prosthesis osteolysis, liver steatosis, and multiple sclerosis. Folate-targeted imaging agents have proven useful in identifying, localizing, and quantifying sites of inflammation in both human patients and animal models of the above diseases. Folate-targeted therapeutic agents offer great promise for the development of highly potent, nontoxic treatment modalities for the same diseases.
MoreTranslated text
Key words
Folate receptor targeting,Activated macrophages,Autoimmune and inflammatory diseases,Rheumatoid arthritis imaging and therapy,Atherosclerosis imaging
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined