Irritability study of Muan ointments on eyes in rabbits

Objective To observe the irritability of Muan ointments on eyes in rabbits and research the best formula of the ointments.Mehtods The 20 rabbits,divided randomly into 5 groups,4 rabbits per group,were treated respectively with Muan1,Muan2,Muan3(in 3 different doses of honey mixed with acyclovir and matrix respectively),ACV(3% Zovirax ophthalmic oint-ment) and matrix(placebo) respectively,three times a day in 4 days.The ocular stimulation and the stimulating degrees in all eyes were measured in the treating period and in 3 days af-ter the treatment.Results After 4 days of administration,the differences between ACV and Mu1 2 were not significant(P0.05) and between ACV and Muan 3 was significant(P0.05);the dif-ference between matrix and Muan1 was not significant(P0.05);the differences between AVC and Muan Muan2 and 3 were significant(P0.01).The ocular stimulation in Muan 1,Muan 2,ACV and matrix groups were disappeared after 3 days of discontinuation,and the differences between them were not significant(P0.05),but the difference between Muan3 and matrix and matrix was significant(P0.05).Conclusion Muan ointment 1 and 2 are safety,which can sur-port the development of new medicine.