DCF方案节拍化疗治疗晚期胃癌的临床观察
Journal of Basic and Clinical Oncology(2012)
Abstract
目的观察DCF方案节拍化疗治疗晚期胃癌的近期疗效及毒副反应。方法 60例晚期胃癌患者随机分为2组,治疗组30例采用DCF方案节拍化疗,对照组30例采用常规DCF方案化疗。结果治疗组CR 3例,PR 16例,SD 6例,PD 5例,有效率为63.3%。对照组CR 2例,PR 15例,SD 6例,PD 7例,有效率为56.7%。2组有效率比较差异无统计学意义(P>0.05)。2组的主要毒副反应为白细胞减少、恶心呕吐、腹泻等,比较差异均有统计学意义(P均<0.05);口腔黏膜炎发生率2组比较差异无统计学意义(P>0.05)。结论 DCF方案节拍化疗治疗晚期胃癌有较高的临床缓解率,毒副反应轻。
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Key words
advanced gastric cancer,docetaxel,DCF regimen,metronomic chemotherapy
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