Ultrasonic Shock-Wave as a Control Mechanism for Liposome Drug Delivery System for Possible Use in Scaffold Implanted to Animals with Iatrogenic Articular Cartilage Defects

Míčková A., k. Tománková, H. kolářová, R. Bajgar, P. kolář, P. Šunka, M. Plencner, R. Jakubová, J. Beneš, l. koláčná, l. Plánka, A. nečas, E. Amler: Ultrasonic Shock- Wave as a Control Mechanism for liposome Drug Delivery System for Possible Use in Scaffold Implanted to Animals with Iatrogenic Articular Cartilage Defects. Acta v et Brno 2008, 77: 285-289. A short liposome exposure to ultrasonic waves with the intensity of I = 2 W/cm 2 at frequency f = 1 MHz was found to be a sufficient tool for liposome opening. In addition, shock-wave proved to be sufficient also for liposome content release. Both methods are useful tools to be used as control mechanisms for drug delivery systems based on liposomes. However, due to better focusing and low non-thermal side effects, shock-waves probably have a markedly higher potential for successful use.