Remote functionalization of SCH 39166: Discovery of potent and selective benzazepine dopamine D1 receptor antagonists

Thavalakulamgara K Sasikumar,Duane A. Burnett,William J. Greenlee,Michelle Smith,Ahmad Fawzi,Hongtao Zhang,Jean E. Lachowicz

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

A series of highly potent dopamine D1 antagonists have been discovered. All compounds showed excellent selectivity over other dopaminergic receptors. Compound 8j showed a modestly improved PK profile than SCH 39166.

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关键词

SCH 39166,Ecopipam,Benzazepine,Dopamine antagonist,Obesity

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